Description

DURAGESIC exposes patients and exceptional customers to opioid addiction, abuse, and misuse risks, which can lead to o.D. And death. Before prescribing DURAGESIC, evaluate each patient’s condition and monitor all patients frequently for the development of those behaviors or situations.

Breathing is life-threatening depression.

Even when used as directed, DURAGESIC should cause dangerous, or fatal breathing despair. Examine for respiratory Depression, especially during DURAGESIC initiation or after a dose increase. DURAGESIC is contraindicated for use as an as-needed analgesic in non-opioid tolerant patients, acute aches, and surgical aches due to the risk of breathing Depression.

Unintentional Exposure

Deaths from a fatal painkiller overdose have occurred after children and adults were accidentally exposed to DURAGESIC. Strict adherence to the recommended handling and disposal guidelines is critical to avoid unintended exposure.

Opioid Withdrawal Syndrome in Infants

Prolonged use of DURAGESIC during pregnancy may also result in infant opioid withdrawal syndrome, which may be severe if not diagnosed and treated, and necessitates regular management with the aid of pediatric professionals. If a highly pregnant woman requires opioids for an extended time, warn her about the risk of the child’s opioid withdrawal syndrome and make sure that appropriate treatment is available.

Interaction of Cytochrome P450 3A4

Furthermore, discontinuing a concurrently used cytochrome P450 3A4 inducer should increase fentanyl plasma attention. Sufferers receiving DURAGESIC and any CYP3A4 substance or inducer should be closely monitored.

Heat Exposure

Exposure of the DURAGESIC software website and surrounding area to direct outside warmth credits, such as heating pads or electric blankets, warmth or tanning lamps, sunbathing, warm baths, saunas, hot tubs, and heated water beds, could increase fentanyl absorption and result in lethal opioid overdose and death. Patients using DURAGESIC systems who develop fever or increased core blood temperature due to strenuous effort are also at risk for increased painkiller exposure. They will require a dose adjustment to avoid drug and death.